血液成分无创光学检测中浮动基准理论的适用性

Availability of Floating-Reference Theory to Non-Invasive Blood Component Measurement by Optical Technology

在浮动基准理论(FRT)应用于血糖无创光学检测研究成果的基础上,进一步研究其在其他血液成分(如胆红素)无创光学检测中的适用性.根据径向检测基准位置存在的条件,经蒙特卡洛模拟的结果表明胆红素测量中难以找到浮动基准位置;而通过研究胆红素与水的置换效应,发现在波长524 nm处吸光度值与胆红素的浓度无关,将该波长作为基准波长,实际测量中可以用于去除背景噪声和环境干扰.综合FRT在血糖及胆红素两种不同血液成分中应用的研究结果表明:对于不同检测成分,在相应的检测波段,浮动基准位置和浮动基准波长有一定的特异性,从而进一步完善和扩展了FRT的应用领域.

Based on the studies of floating-reference theory （FRT） applied to non-invasive optical blood glucose sensing, this paper further investigated the availability of FRT in measuring other blood compo- nents, like bilirubin. According to the conditions of the radial reference location, the results of Monte Carlo simulation show no appearance of radial reference location in non-invasive bilirubin measurement. While the study on the replacement effect of bilirubin and water shows that, at the wavelength of 524 nm, the absorption value of bilirubin solution has no relationship with its concentration. Therefore, this wave- length is regarded as the reference wavelength, and in the further study, it can be used to remove the in- fluence caused by the change of environment and background. In general, the application of FRT in blood glucose and bilirubin shows the specificity of floating reference location and floating reference wave- length in measuring different blood components by optical technology within the designated wavelength, which further improves and extends the application of FRT.