COPD急性发作期高敏C-反应蛋白的检测及其与病情的关系

Detection of hs-CRP in acute exacerbation of chronic obstructive pulmonary disease and its relationship with disease

目的:探讨高敏C-反应蛋白(hs-CRP)在慢性阻塞性肺疾病急性发作期(AECOPD)的变化及其与患者病情的关系。方法:选择60例AECOPD患者做为观察组,以50例稳定期COPD患者为对照组,比较两组血清hs-CRP及肺功能的差别,并对观察组患者肺功能与hs-CRP关系进行相关性分析。结果:观察组及对照组血清hs-CRP水平分别为(57.31±9.42)、(5.69±0.24),差异有统计学意义(P<0.01);hs-CRP与肺功能FEV1、FEV1/FVC显著相关。结论:AECOPD患者血清hs-CRP水平显著升高,与肺功能损害程度正相关,是COPD患者急性加重期感染的敏感指标。

：To explore the change of hsCRP in acrte exacerbation of chronic obstructive pulmonary disease （COPD） and its relationship with disease. Methods： Sixty patients with AECOPD were included as observation group and 50 cases with stable COPD as control group. Serum hsCRP and lung function were detected and compared between the two groups. Relationship between the serum hsCRP and lung function was also analyzed with Pearson method. Results： Serum lever of hsCRP of the observation group and control group was significantly different F（57. 31± 9. 42） vs. （5.69±0.24）P0.01） ]; Pearson analysis showed that hs CRP had a significant correlation with FEV1 and FEV1/FVC. Conclusions： Serum hs CRP level significantly increases in AECOPD patients showing a significant correlation with FEV1 and FEV1/FVC and is a sensitive index for evaluating AECOPD.