中药骨筋宝汤对膝关节骨性关节炎患者血清SOD、NO及MDA水平的影响

Influence of Gujing Bao Tang on SOD,NO and MDA levels in patients with osteoarthritis of the knee

目的:探讨中药骨筋宝汤对膝关节骨性关节炎患者血清超氧化物歧化酶(SOD)、一氧化氮(NO)及丙二醛(MDA)水平的影响,为进一步指导临床治疗提供依据。方法:60例膝关节骨性关节炎随机分为两组,每组30例,A组常规治疗,B组辅助中药干预组,分别在治疗后的3、6、9周比较两组血清中SOD、NO及MDA的水平。结果:与B组比较,A组SOD、NO及MDA水平均明显增高(P<0.01);B组SOD各相同时间点数值特别是峰值显著低于A组(P<0.01);A组自3周起MDA水平显著升高,至9周维持在较高水平,相同时间点B组各值均明显低于A组(P<0.01)。结论:中药骨筋宝汤可降低自由基损伤因子MDA和NO,升高自由基清除剂SOD水平,促进对膝关节骨性关节炎的治疗作用。

To explore the influence of Gujing Bao Tang on SOD, NO and MDA levels in patients with osteoarthritis of the knee, in order to provide guidance for further study, Methods;A total of 60 patients with knee osteoarthritis were randomly divided into A group of conventional treatment, Bgroup and Chinese herbs in the intervention group A （30 cases） and group B, which was treated with routine therapy, and TCM treatment group. After treatment of 3w, 6w, 9w, serum SOD, NO and MDA lev els of the two groups were detected and compared. Results.SOD, NO and MDA levels of group A were all increased comparing with that of group B （P〈0.01） ; SOD levels in group B were all lower than that in group A at the same points, especially the summit value. MDA levels in group A started to increase from week 3, and maintained till week 9, MDA levels in group A were also higher than that in group B at different time points（P%0.01） Conclusions. Traditional Chinese medicine Gujing Bao Tang can reduce free radical damage factor MDA and NO, increase levels of free radical scavengers SOD to promote the treatment effects for osteoarthritis of the knee.