多库酯钠联合莫沙比利治疗老年性便秘临床观察

Observation of docusate sodium combined with mosapride in treatment of senile constipation

目的:探讨多库酯钠联合莫沙比利治疗老年性便秘的临床疗效。方法:将符合标准的104例老年慢性功能性便秘患者随机分成A组(30例)、B组(32例)和C组(42例),A组予多库酯钠片口服治疗,B组予莫沙必利片口服治疗,C组采用联合用药治疗,3组疗程均为14d。结果:所有患者治疗两周后,A组、B组和C组的总有效率分别为76.67%、71.88%和92.86%,A组、B组和C组相比差异有统计学意义(P<0.05)。结论:多库酯钠联合莫沙比利治疗老年慢性功能性便秘疗效满意,不良反应少。

To integrative clinical efficacy of docusate sodium combined with mosapride in treatment of senile constipation. Methods：A total of 104 patients with this disease were randomly divided into three groups including group A （30 cases） , group B （32 cases） and group C （42 cases） and were all treated for same course of 14 d. Group A only received docusate sodium treatment, patients in group B only received mosapride treatment, while others received docusate sodium combined with mosapride therapy. Results：After 14d of treatment, the total efficiency was 76.67%, 71.88%and 92.86% for group A, B and C, respectively. Comparing with group A, B with group C there was significant differences （P〈 0.05 ）. Conclusions：The treatment of senile constipation with docusate sodium and mosapride is an effective method and has a significant curative effect.