原发性肝内胆管结石的病因学研究

STUDIES ON THE ETIOLOGY OF PRIMARY INTRAHEPATIC STONE

目的 了解原发性肝内胆管结石的形成原因。方法 采用文献回顾的方法对原发性肝内胆管结石的病因加以综述。结果 原发性肝内胆管结石的形成主要与细菌感染、胆汁淤滞、寄生虫感染、先天性解剖异常以及免疫反应有关 ;进一步研究发现与代谢、营养、环境、种族、遗传及基因突变相关。结论 原发性肝内胆管结石的形成是多因素作用的结果 ,与胆道感染。

Objective To study the etiology of primary intrahepatic stones. Methods The literatures in the recent years on the etiology of intrahepatic stone were revieved.Results The formation of intrahepatic stone mainly caused by bacteria infection, parasitic infestation, bile stasis, congenital anatomic abnormalities and immunoreaction of bile tract. Further investigation found that metabolic, low protein diet, environment and ethnic factors and gene mutation were considered to play important roles in the formation of the intrahepatic stone. Conclusion The formation of intrahepatic stone is complex and are result of multiple factors. It closely related to the infection and stasis of the bile duct.