氟比洛芬酯超前镇痛对肱骨骨折患者术后镇痛的影响

Preemptive analgesic effect of flurbiprofen axetii on patients with fracture of humerus after surgery

目的:观察氟比洛芬酯用于骨科手术时超前镇痛的作用效果。方法:将96例ASA I～Ⅱ级行肱骨骨折手术的患者随机分为观察组和对照组。观察组术前15min静脉缓注氟比洛芬酯1mg/kg;对照组术前15min静脉缓注脂微球注射液0.1 mL/kg。所有受试患者术后均行患者自控静脉镇痛(PCIA)。分别记录术后2h、4h、6h、12h、24h的视觉模拟评分(VAS)、24h芬太尼用量和不良反应,并在镇痛结束后统计患者对镇痛治疗的总体满意度。结果:术后2h、4h、6h、12h、24hVAS评分观察组与对照组差异无统计学意义(P>0.05);术后24h观察组的芬太尼用量(580.4±38.2)μg低于对照组的(720.7±47.6)μg(P<0.05);两组不良反应发生率的差异有统计学意义(P<0.05);两组患者对镇痛治疗总体满意度(Ⅴ级)差异有统计学意义(P<0.05)。结论:肱骨骨折手术超前应用氟比洛芬酯,能减少术后芬太尼的用量,减轻不良反应的发生,并能提高患者对镇痛治疗的总体满意度。

[ABSTRACT] Objective： To observe the preemptive analgesic effect of flurbiprofen axetil on postoper- ative pain relief. Methods：Ninetysix humerus fracture patients （ASA Ⅰ-Ⅱ ） with surgery were randomly assigned into two groups. The patients in group I（n=48） received intravenous injection of flurbiprofen axetil 1 mg/kg 15 rain before surgery,and those in group Ⅱ （n±48） had intravenous injection of placebo 0.1 mL/kg. Postoperative analgesia efficacy was assessed by visual analog scales（VAS） at2 h, 4 h, 6 h, 12 h, 24 h after surgery. Fentanyl requirements and adverse effects were recorded at 24 h after surgery. The overall satisfaction to analgesic therapy was evaluated. Results： There was no significant difference in VAS between two groups at 2 h, 4 h, 6 h, 12 h, 24 h （P〈0.05）. Requirements of fentanyl were significantly low in group I [（580.44-38.2） /μg] than those in group Ⅱ [（720.74-47.6） μg] （P〈0.05）. There was significant difference between the two groups in adverse effects （P〈0.05）. Conclusions： Flurbiprofen axetil can produce preemptive effect, reduce the requirements of fentanyl and the adverse effect, and enhance the quality of analgesia.