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氟比洛芬酯超前镇痛对肱骨骨折患者术后镇痛的影响 被引量:8

Preemptive analgesic effect of flurbiprofen axetii on patients with fracture of humerus after surgery
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摘要 目的:观察氟比洛芬酯用于骨科手术时超前镇痛的作用效果。方法:将96例ASA I~Ⅱ级行肱骨骨折手术的患者随机分为观察组和对照组。观察组术前15min静脉缓注氟比洛芬酯1mg/kg;对照组术前15min静脉缓注脂微球注射液0.1 mL/kg。所有受试患者术后均行患者自控静脉镇痛(PCIA)。分别记录术后2h、4h、6h、12h、24h的视觉模拟评分(VAS)、24h芬太尼用量和不良反应,并在镇痛结束后统计患者对镇痛治疗的总体满意度。结果:术后2h、4h、6h、12h、24hVAS评分观察组与对照组差异无统计学意义(P>0.05);术后24h观察组的芬太尼用量(580.4±38.2)μg低于对照组的(720.7±47.6)μg(P<0.05);两组不良反应发生率的差异有统计学意义(P<0.05);两组患者对镇痛治疗总体满意度(Ⅴ级)差异有统计学意义(P<0.05)。结论:肱骨骨折手术超前应用氟比洛芬酯,能减少术后芬太尼的用量,减轻不良反应的发生,并能提高患者对镇痛治疗的总体满意度。 [ABSTRACT] Objective: To observe the preemptive analgesic effect of flurbiprofen axetil on postoper- ative pain relief. Methods:Ninetysix humerus fracture patients (ASA Ⅰ-Ⅱ ) with surgery were randomly assigned into two groups. The patients in group I(n=48) received intravenous injection of flurbiprofen axetil 1 mg/kg 15 rain before surgery,and those in group Ⅱ (n±48) had intravenous injection of placebo 0.1 mL/kg. Postoperative analgesia efficacy was assessed by visual analog scales(VAS) at2 h, 4 h, 6 h, 12 h, 24 h after surgery. Fentanyl requirements and adverse effects were recorded at 24 h after surgery. The overall satisfaction to analgesic therapy was evaluated. Results: There was no significant difference in VAS between two groups at 2 h, 4 h, 6 h, 12 h, 24 h (P〈0.05). Requirements of fentanyl were significantly low in group I [(580.44-38.2) /μg] than those in group Ⅱ [(720.74-47.6) μg] (P〈0.05). There was significant difference between the two groups in adverse effects (P〈0.05). Conclusions: Flurbiprofen axetil can produce preemptive effect, reduce the requirements of fentanyl and the adverse effect, and enhance the quality of analgesia.
出处 《海南医学院学报》 CAS 2012年第3期404-406,共3页 Journal of Hainan Medical University
基金 中国高校医学期刊临床专项资金项目(11221080)~~
关键词 超前镇痛 PCIA 氟比洛芬酯 芬太尼 Preemptive analgesia PCIA Flurbiprofen axetil Fentanyl
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