ESWL前后肾内血管阻力指数和尿中GAL与NAG检测的意义

Changes in intrarend vascular resistance index and the levels of NAG and GAL before and after ESWL

目的 :探讨肾内血管阻力指数 ( RI)和尿液中 β- D半乳糖苷酶 ( GAL)、N-乙酰 - β- D氨基葡萄糖苷酶 ( NAG)三者与 ESWL所致肾损伤及其修复过程的关系。方法 :检测 50例单侧肾结石患者 ESWL前后肾内血管 RI和尿液中 GAL与 NAG。结果 :ESWL后肾内血管 RI显著升高 ( P<0 .0 1 ) ,尿中 NAG水平明显上升 ( P <0 .0 5) ,而 ESWL后 1～ 2周时尿中 GAL水平才开始升高 ,且 GAL/NAG值呈明显的上升趋势。结论 :ESWL所致肾损伤与肾内血管 RI和尿中 NAG水平相关 ,肾损伤修复时限长短与尿中 GAL水平的变化相关 ,GAL/NAG值的变化可能是肾损伤和修复过程中最有效的临床监测指标。

Purpose:To evaluate intrarenal vascular resistance index (RI) and the levels of β D galactosidase (GAL) and N acetyl β D glucosaminidase (NAG) in urine before and after ESWL.Methods:RI,the levels of NAG and GAL were measured in 50 renal lithiasis cases treated by ESWL.Results:RI in the treated kindeys and NAG in urine significantly increased after ESWL (P< 0.01 ),whereas,RI in the contralateral kindeys has no difference statistically before and after ESWL.About one and two weeks after ESWL the levels of GAL gradually elevated and the ratios of GAL/NAG had an increasing tendency.Conclusions:RI、NAG and GAL might seve as effective markers to treat the renovascular damage,the ratio of GAL/NAG is more sensitive than simple NAG or GAL as an indicator of the intrarenal injury and recovery after ESWL.