临床药物治疗中氨茶碱与甲泼尼龙琥珀酸钠注射液配伍问题的分析

Analysis of conflicting information about the compatibility of aminophylline with methylprednisolone sodium succinate injection involved in clinical use of drugs

目的对氨茶碱与甲泼尼龙琥珀酸钠是否可注射配伍使用的问题进行系统分析,为抢救与治疗必须严格限制液体用量的危重患者联合使用两药时提供合理的指导性建议。方法 SPSS15.0软件统计分析该院2006～2009年住院期间配伍使用氨茶碱与甲泼尼龙琥珀酸钠的589例患者病例。检索国外权威数据库与国内相关资料,对返回信息进行汇总分析。结果临床治疗中普遍采用氨茶碱与甲泼尼龙琥珀酸钠联合用药的治疗方案,其中在呼吸内科与危重症监护病区中,两种药物的联用更为常见。国外权威数据库的检索结果均表明,两药可配伍使用;国内相关资料则表明,两药禁止配伍注射。结论国内目前相关资料迥异于国外权威数据库,有待修订。氨茶碱与甲泼尼龙琥珀酸钠在常规临床使用条件下不存在配伍禁忌,尤其在抢救必须严格限制静脉输注液体量的危重症患者时,两药配伍使用以控制液体输注量尤为必要。

【Objective】 To analyze drug compatibility of aminophylline with methylprednisolone sodium succinate systematically to offer reasonable advice for physicians and pharmacists about combined use of these two drugs involved in rescuing and treating seriously ill patients who must be restricted intravenous transfusion volume.【Methods】 SPSS15.0 was used to analyze patients in the first affiliated hospital of Guangxi medical university from 2006 to 2009 who were received intravenous injection of aminophylline combined with methylprednisolone sodium succinate.To search foreign authentic information databases and to refer domestic related information,the retrieving results were analyzed.【Results】 Aminophylline combined with methylprednisolone sodium succinate was a regular treatment in clinical therapy,especially at Respiratory Medicine and Intensive Care Unit.Compatibility of this combination was demonstrated by foreign authentic information databases,but incompatibility of this combination was denoted by domestic information.【Conclusions】 The domestic relative information,is conflict to foreign authentic information databases,should be amended.There was compatibility of these two drugs in regular clinical treatment,especially when rescuing severe patients who must be strictly restricted intravenous transfusion volume,the combination administration is inevitable.