甾体含氮化合物的合成及抗肿瘤活性研究

Synthesis and antitumor activities of steroidal nitrogen compounds

当甾体化合物中引入杂原子时,其化学性质受杂原子影响,生理活性也常常发生改变。从简单的甾体化合物出发,合成出6个化合物并对其中5个化合物进行了体外抗肿瘤活性研究。

The heteroatom N which was introuced into steriodal compound affects the chemical properties of that particular steroid and often results in alterations of its biological activities.In the work,five steroidal nitrogen compounds were synthetized and the antitumor activities of the compounds were valuated.