慢性肝病与乙、丙型肝炎病毒感染关系的探讨

Chronic liver disease and hepatitis B and hepatitis C virus infection

目的 探讨慢性肝病与乙、丙型肝炎病毒感染的关系。方法 EIA法检测HBV感染指标 (两对半系统 )及抗HCV ;PCR法检测HBVDNA ,反转PCR法检测HCVRNA。结果 32 8例慢性肝病患者中 ,HBV感染率明显高于HCV感染率 (P <0 .0 5 ) ,肝癌患者中HBV、HCV重叠感染率明显高于慢性肝炎组 (P <0 .0 5 )。结论 本地区慢性肝病仍以HBV感染为主 ;HBV、HCV重叠感染对肝癌的发生似有相加作用。

Objectives To study the relation beetween chronic liver disease and HBV and HCV Infection.Methods Serological markers of HBV and HCV infection were tested by EIA;HBVDNA by PCR;HCVRNA by RT-PCR.Results The infection rate of HBV was significantly higher than that of HCV, (P<0.05);superinfection rate of HBV and HCV of Hepatocellular Carcinoma was significantly higer than that of chronic hepatitis(P<0.05). Conclusions HBV was still the main pathogenic factor of chronic liver disease in Heze area,superinfection may accelerate the progress of liver cancer.