慢性阻塞性肺病和哮喘患者痰液嗜酸细胞阳离子蛋白水平比较

Comparison of sputum eosinophil cationic protein levels in chronic obstructive pulmonary disease and bronchial asthma

目的对比观察慢性阻塞性肺病（ＣＯＰＤ）和哮喘患者痰液嗜酸细胞阳离子蛋白（ＥＣＰ）水平．探讨两种疾病发病机理的异同。方法采用荧光酶标法对ＣＯＰＤ和哮喘患者痰液ＥＣＰ水平进行检测。结果哮喘组痰液ＥＣＰ为（２７８．４±１４９．８）μｇ／Ｌ，显著高于ＣＯＰＤ组（７８．４±４６．４）ｕｇ／Ｌ，ｐ＜０．０５。哮喘组痰液ＥＣＰ水平与呼吸秒率（ＦＥＶ１％）呈显著负相关（ｒ＝－０．６８，ｐ＜０．０５）．而ＣＯＰＤ组两者之间未显示出明确的相关性。结论ＣＯＰＤ和哮喘息者虽然都存在着气道炎症，但两者的性质不同，痰液ＥＣＰ浓度测定有助于两者的鉴别。

Objective To compare the levels of the sputum (ECP) in chronic obstructive pulmonary disease (COPD) and bronchial asthma and study their differences in pathogenesis. Methods We measured the levels of the sputum ECP in COPD and bronchial asthma with fluorenscence in labelled enzyme. Results In asthmatic sputum, ECP levels [(278.4 ± 149.8)μ g/l] was significantly higher than that in COPD [(78.4 ±46.4) μ g/L, P<0.05], there was a distinctly negative relationship between ECP and EEV1%. Conclusion Sputum analysis can help identify asthma and COPD, and their pathogenesis is different.