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血小板第4因子的造血保护作用 被引量:2

The hemaprotective effects of platelet factor 4
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摘要 目的 :了解血小板第 4因子对60 Co 射线照射后小鼠体内造血的作用。方法 :实验鼠用PF4注射两次 ,间隔 6h ,第 2次注射后 2 0h给予 7.5Gy的60 Co 射线一次性全身照射 ,第 8天时检查粒 巨噬系集落形成单位 (CFU GM)及细胞周期的变化 ;第30天时检查小鼠的存活率。结果 :PF4注射 8d后能明显增加CFU GM及骨髓单个核细胞的数量 ;30d后实验鼠的存活率及存活期亦见增加。结论 :PF4能延长小鼠的生存时间 ,增加小鼠的存活率 ,加速体内CFU GM的恢复。 Objective:[WT5BZ]TO study the effects of platelet factor 4(PF4) on hematopoietic progenitors in mice treated with 60 Co  ray.[WT5HZ]Methods:[WT5BZ]The mice were injected with PF4 twice at 6 h intervals,and 20 h after the second injection,they were given one irradiation of 7.5 Gy 60 Co  ray.The number of CFU GM and mononuclear cell of bone marrow and cell cycle were examined 8 days later.The survival condition during 30 days was observed.[WT5HZ]Results:[WT5BZ]Administration of PF4 resulted in a significant increase in the numbers of CFU GM and mononuclear cell of bone marrow on day 8th when it was compared with 60 Co  alone,and morever,survival rate and survival days also rised 30 days later.[WT5HZ]Conclusion:[WT5BZ]PF4 could prolong the life,increase survival rate and accelerate proliferation of CFU GM.
出处 《西北国防医学杂志》 CAS 2000年第1期6-8,共3页 Medical Journal of National Defending Forces in Northwest China
关键词 造血功能 血小板第4因子 造血保护 Hematopoietic function Platelet factor 4 Hemaprotection
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