生姜与干姜药理活性的比较研究

Comparative studies on pharmacological effects of dried and fresh gingers

目的 :研究生姜与干姜在药效上有无差异 ,为临床上合理使用二药提供实验依据。方法 :以生姜 (ZingiberofficinaleRosc)药效作用为主 ,采用止呕、解热、缓和眼部刺激比较研究了生、干姜煎剂的药理活性。结果 :生姜煎剂可显著抑制鸽子的呕吐次数 ,减少呕吐只数 ;对致热大鼠有显著的退热作用 ;并可显著降低生半夏对家兔眼睑结膜的刺激作用。结论 :干姜煎剂与生姜煎剂在相同的剂量下则作用较弱。因此 ,药用时干姜不宜代替生姜。

OBJECTIVE:To study the difference in pharmacological activities between fresh ginger and dry ginger.METHODS:Pharmacological studies on antiemetic,antipyretic and mitigation of irritation.Activities of fresh and dried Rhizoma Zingiberis Recens were comparatively carried out.RESULTS:The decoction of fresh Rhizoma Zingiberis Recens singificantly decreased the vomiting frequency and incidence in pigeons,brought down the fever induced in rats,and mitigated the irritation of eyelid conjunctiva induced by fresh Rhizoma Pinelliae in rabbits.CONCLUSION:The dried ginger showed lower activity than the fresh ginger.The results suggested that the fresh ginger should not be replaced by the dried one in clinical application.