布洛芬透皮吸收制剂的家兔体内药代动力学研究

Study on pharmacokinetics of transdermal ionphoretic ibuprofen in rabbits

目的 :进行布洛芬离子电导入经皮给药系统家兔体内药代动力学参数和生物等效性评价 ,为布洛芬离子电导入经皮给药系统的临床应用提供理论依据。方法 :采用反相高效液相色谱法测定布洛芬不同给药途径给药后不同时间家兔血药浓度 ,计算药代动力学参数并进行生物等效性评价。结果 :离子导入给药法的吸收速度快 ,AUC及cmax分别为透皮给药的 3.7倍和5倍。结论 :布洛芬离子导入经皮给药系统有望成为新的全身给药方式。

OBJECTIVE:To furnish theoretical evidence for clinical application of transdermal ionphoretic ibuprofen delivery system by comparing the pharmacokinetic parameters and the bioequivalence of ibuprofen in rabbits.METHODS:The ibuprofen was given in different ways and the blood samples were collected at different times and the concentrations were determined by reversed phase high performance liquid chromatography (HPLC).The pharmacokinetic parameters and the bioequivalence of ibuprofen were compared.RESULTS:It was showed that the absorption rate of transdermal ionphoretic ibuprofen delivery system was faster than that of traditional peroral mode.The AUC and the c max of the former was as 3.7 times and 5 times as the absorption through skin respectively.CONCLUSION:The transdermal ionphoretic ibuprofen delivery system may be a new mode for administration.