我国老年痴呆研究概况

A Summary of Dementia Studies in China

检索中、西文大型权威数据库(包括CNKI、PubMed、Elsevier and PsycInfo)中有关中国老年人口的痴呆研究文献13037篇,对这些文献的分析结果表明:1.研究主题涉及痴呆的流行病学(1.68%)、痴呆的发病机制与风险因素(37.4%)、痴呆的临床表现与诊断(9.8%)、痴呆的治疗与干预(40.2%)以及关于痴呆的其它研究(10.9%);2.不同研究所报道的我国痴呆患病率彼此差异很大,60岁及以上人口的痴呆患病率平均为3.5%(95%CI 2.8-4.2),且患病率随年龄而增长;3.痴呆的发病机制非常复杂,是由内外多种因素交互作用的结果,其中,有些风险因素的结果比较一致,有些保护因素的结果也有共识,但不少因素的影响尚需进一步探讨;4.研究认为,今后需要增强样本代表性、完善检测与诊断工具、在加强痴呆流行病学和临床症状研究的同时,进一步加强痴呆患病的延缓因素研究,以便为老年痴呆的护理和干预提供客观的科学依据。

This article summarizes the main studies on dementia in Chinese population based on indexing 13037 papers in Databases of Chinese CNK1 and English PubMed, Elsevier and PsycInfo by key words related to dementia （or Alzheimer） in Chinese population. The results show that： 1. The dementia studies in China concern epidemiological investigation （1.68%）, pathological mechanisms of dementia （37.4%）, clinical symptoms and diagnosis of dementia （9.8%）, treatment and intervention of dementia （40.2%）, and some other kind of studies （10.9%）; 2. the reported prevalence of dementia in Chinese populations varies widely, with estimates of average prevalence at 3.5% （95% CI 2.8-4.2） among Chinese population aged 60 and over, which grows with age; 3. the pathological mechanisms of dementia is complicated with interactive factors, of which some high risk factors and protective factors have been identified while many other factors need to be further examined. The authors, therefore, suggest that detection of factors that may delay the onset and slow the progression for the prevention of dementia be emphasized in the future study, laying a solid foundation for medicare and preventive treatment.