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雷诺嗪的合成研究

A Study of Synthesis of Ranolazine
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摘要 雷诺嗪是一种抗心绞痛药物,在生物医学领域中具有重要意义。本文主要介绍了雷诺嗪的合成工艺和一些工艺上的优化,并对这些优化的步骤进行了综述。 Ranolazine is an anti-angina drug. It has strong interest in the biomedical field. The paper describes the mainly technology of synthesis of ranolazine and to optimize the technology. The optimization of these steps was also reviewed.
作者 韩生华 马鹏飞 孟双明
机构地区 山西大同大学化学与化工学院
出处 《山西大同大学学报（自然科学版）》 2012年第1期35-36,共2页 Journal of Shanxi Datong University(Natural Science Edition)
关键词 雷诺嗪 合成 心绞痛 Ranolazine synthesis angina pectoris
分类号 O615.42 [理学—无机化学]
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参考文献7

  • 1Woff A A,Rotmen S H H.Metablic Approaches to the Treatment of Ischemic Heart Disease the clinicians Perspective[J].HeartFailRew(s1382-4147),2002,7(2):187-203.
  • 2Eva A C,Tibor G,Kalman H.Process for the Preparation of Piperazine Derivatives EP:0483932[P].1991.
  • 3Kluge A F,Clark R D.Cardioselective Aryloxy-and Arylthio-Hydroxypropylene-Piperazinyl Acetanilides Which Affect CalciumEntry US:4567264[P].1986.
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  • 5秦明利,陈新华,陈思顺,陶京朝.雷诺嗪的合成工艺研究[J].信阳师范学院学报（自然科学版）,2007,20(2):226-229. 被引量：2
  • 6陆文超,李瑛琦,赵祥麟,郭春,周凯.雷诺嗪的合成[J].中国医药工业杂志,2004,35(11):641-642. 被引量：5
  • 7李树春,黄河清,李中军.新型抗心绞痛药雷诺嗪的合成研究[J].中国药物化学杂志,2003,13(5):283-285. 被引量：7

二级参考文献13

  • 1Eva AC, Tibor G, Kalman H. Process for the preparation of piperazine derivatives [ P]. EP: 0483932 A1,1991 - 10- 31.
  • 2McCormack JG, Stanley WC, Wolff AA. Ranolazine, a novel metabolic modulator for the treatment of angina[J]. Gen Pharm, 1998, 30(5) :639 - 645.
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  • 7Kluge AF, Clark RD, Strosberg AM, et al. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which effect calcium entry [P]. US: 4567264, 1986-01-28; EP: 126449, 1984-11-28. (CA 1985, 102: P166777h)
  • 8Baumgarter HE. Organic Syntheses [M]. Coll Vol V, New York: John Wiley, 1973.88-91.
  • 9WOFF A A,ROTMENSCH HH.Metablic Approaches to the Treatment of Ischemic Heart Disease:the Clinicians' Perspective[J],Heart Fail Rev(S1382-4147),2002,7(2):187-203.
  • 10EVA AC,TIBOR G,KALMAN H.Process for the Preparation of Piperazine Derivatives.EP:0483932[P].1991-10-31.

共引文献9

山西大同大学学报（自然科学版）
2012年 第1期

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