大茴香醛改性海藻酸钠凝胶的制备及释药性能

Preparation of alginate gel modified by anise aldehyde and controlled release

在酸催化下使海藻酸钠与对甲氧基苯甲醛(又名大茴香醛)发生缩醛化反应,使其疏水改性,并将其制备成凝胶。利用红外(FTIR)、荧光、透射电镜(TEM)、扫描电镜(SEM)、紫外、热重分析(TGA)对产物进行了表征。结果表明,大茴香醛成功地与海藻酸钠发生了反应。该凝胶可以作为药物载体对牛血清白蛋白进行包埋释放,结果发现,改性后的产物其载药率和缓释性能比未改性的海藻酸钠有了一定的提高。

Hydrophobically modified alginate were obtained through acetalization of alginate with p-methoxy benzaldehyde catalysted by an acid.The modified alginate was characterized by FTIR spectra,fluorescence,transmission electronic microscopy,scanning electronic microscopy,UV spectrum,thermal analysis.The modified alginate hydrogel was used as a drug carrier for encapsulation and release of bovine serum albumin.The results showed that drug loading ability and slow release were observed.