小儿先天性心脏病围手术期两种抗菌药疗效及经济学比较

Effectiveness and Economics Comparison of Two Kinds of Antibiotics During the Congenital Heart Disease Preoperative Period

目的:回顾性研究我院儿先天性心脏病围手术期预防性应用抗菌药方案,比较两组患者住院时间、术后感染率、住院费用、抗菌药费用等方面的差别,探讨围手术期抗茵药的选择。方法:选取2)10年1～6月行先天性心脏病手术病历341份,按预防性使用抗菌药品种分为头孢替安组(272例)和头孢曲松组(69例),对观测指标进行统计学处理及数据分析。结果:两组患者的抗菌药预防使用时间、抗菌药日均费用、抗菌药总费用等三项指标差异显著(P<0.05);头孢曲松组较头孢替安组抗菌药使用时间缩短约0.5 d,日均费用及抗菌药总费用分别节省约41元和360元。结论:两组患者术后感染率差异无统计学意义,但头孢曲松组在经济学方面更有优势,可以有效降低医疗费用,减轻患者经济负担。

Objective： To discuss the antibiotics selection during the preoperative period of children with congeni.- tal heart disease by comparing the differences between two groups using antibiotics in hospitalization time, infection rates ,, hospital costs and fees of antibacterial drugs. Methods：341 cases of congeni＇tal heart surgery were selected during Januat3! to June 2010. All the patients were divided into two groups： cefotiam group （, 272） and ceftriaxone group （69） by different-- ly using prophylactic antibiotics. The observed data were statistically analyzed. Results：There were significant difference in the observed data of the antibiotics using time, daily cost of average antimicrobial drugs and total cost of antimicrobia]l drugs （P 〈 0.05 ） from two groups. Conclusion：There were no significant differences in the infection rates after surgery within two groups, However, ceftriaxone used could effectively reduce patients＇ health care costs and financial burden.