宫腔镜注入氨甲喋呤治疗早期输卵管妊娠疗效分析

Hysteroscopic tubal methotrexate injection in the treatment of early tubal pregnancy

目的探讨宫腔镜下输卵管插管注入氨甲喋呤辅以口服米非司酮治疗早期输卵管妊娠的临床效果。方法选择110例早期输卵管妊娠患者作为研究对象,按入院先后随机分为观察组及对照组,每组55例,观察组在宫腔镜引导下行输卵管插管注入氨甲喋呤,同时辅以口服米非司酮治疗;对照组肌注氨甲喋呤,同时辅以口服米非司酮。比较两组的临床治疗指标。结果观察组的成功率明显高于对照组,而血β-hCG恢复至正常的时间、附件包块消失时间短于对照组,不良反应发生率少于对照组,差异有统计学意义(P<0.05)。结论输卵管注入氨甲喋呤辅以口服米非司酮治疗早期输卵管妊娠疗效显著,优于肌肉注入氨甲喋呤辅以口服米非司酮,值得临床推广应用。

Objective To explore the clinical effect of tubal methotrexate （MTX） injection tube hysteroscopic guided, Supplemented with oral mifepristone in the treatment of early tubal pregnancy. Methods By order of admission, 110 patients with early tubal pregnancy were randomly divided into observation group and control group （n = 55 ）. In hysteroscopic guidance, observation group was injected through the tube to MTX and supplemented by oral administration of mifepristone treatment. Control group was injected MTX line muscle and supple- mented by oral administration of mifepristone treatment. The clinical indicators were compared between the groups. Results Observation group was significantly higher success rate, serum 13 - hCG returued to normal time, adnexal mass disappeared a short time in the control group, adverse reactions occurred in less than the control group, the difference between the groups was significant （ P 〈 0. 05 ）. Conclusion Tubal MTX injection combined with oral mifepristone treatment of early tubal pregnancy was significant effect than muscle injection of MTX combined with oral mifepristone, It is worthy of clinical application.