甲泼尼龙联合干扰素治疗复发缓解型多发性硬化症疗效观察

Observation on the effect of methylprednisolone combined with interferon in the treatment of patients with relapse remitting multiple sclerosis

目的观察甲泼尼龙冲击疗法（MPPT）联合干扰素治疗复发缓解型多发性硬化症（MS）的疗效。方法90例患者被随机分为观察组及对照组，每组各45例。观察组在急性期采用MPPT治疗，缓解期采用干扰素-β1α（IFN—β1α）治疗；对照组仅在急性期采用MPPT治疗。结果MPPT急性期总有效率达98．9％。观察组采用IFN—β1α治疗期间，MS复发率为30．2％，对照组随访2年复发率为53．3％，观察组显著低于对照组（P〈0．05）。结论对于复发缓解型MS，在急性发作时采用MPPT疗法缓解急性期症状，缓解期采用IFN—β1α预防复发，是较好的治疗方案。

Objective To explore the effect of methylprednisolone combined with interferon in the treatment patients with relapse remitting multiple sclerosis. Methods 90 patients with relapse remitting multiple sclerosis were randomly divided into experimental group and treatment group. The experimental group during the acute stage with methylprednisolone pulse therapy, remission with interferon β（IFN-β） treatment;the control group only in the acute phase with methylprednisolone pulse therapy. Results The total effective rate of methylprednisolone pulse therapy in the acute stage was 98.9%. Experimental group during the treatment with IFN-β1α, relapse rate was 30.2 % ;patients in the control group were followed up for two years, the recurrence rate was 53.3%. Experimental group and control group was significantly different （ P 〈 0.05 ）, the experimental group was significantly lower than the control group. Conclusion For relapsing-remitting MS, using MPPT could relieve acute symptom in the acute stage, and in remission using of IFN-β1α relapse prevention was a good choice for clinicians.