多西他赛、顺铂联合同期放疗治疗中晚期宫颈癌的疗效观察

Observation on the effect of docetaxel, cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer

目的观察多西他赛、顺铂联合同期放疗对中晚期宫颈癌的临床疗效。方法将64例中晚期宫颈癌患者随机分为两组，对照组32例采用放射治疗，观察组32例在对照组基础上采用多西他赛与顺铂同期化疗。比较两组的临床疗效和不良反应发生情况。结果观察组总有效率为84．4％，明显高于对照组的59．4％（x^2=4．07，P〈0．05）。观察组骨髓抑制、恶心呕吐发生率分别为43．8％（14／32）、21．9％（7／32），略高于对照组的31．3％（10／32）、12．5％（4／32），但差异均无统计学意义（x^2=1．09，1．17，均P〉0．05）。结论中晚期宫颈癌采用多西他赛与顺铂同期放化治疗，能够明显提高疗效，并且不会增加不良反应的发生率，值得临床推广应用。

Objective To explore the effect of docetaxel, cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer. Methods 64 patients with advanced cervical cancer were randomly divided into two groups, observation group with 32 cases who were treated with docetaxel and cisplatin concurrent chemotherapy and radiotherapy and control group with 32 cases were treated with radiotherapy. The clinical effect and adverse reaction between two groups were compared. Results The total effective rate in observation group was 84.4%, which significantly higher than that in control group of 59.4% （ x^2 = 4.07, P 〈 0.05 ）. There were no significant differences in incidences of bone marrow suppression and nausea and vomiting between two groups （ x^2 = 1.09,1.17, all P 〉 0.05 ）. Conclusion Docetaxel, cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer could enhance clinical effect, and not increase the adverse reaction incidence, which could be applied in clinic.