无创正压通气治疗对肺心病患者脑钠肽的影响

influence of noninvasive positive pressure ventilation treatment on the brain natriuretic peptide level of patients with pulmonary heart disease

目的探讨无创正压通气对肺心病患者脑钠肽（BNP）水平的影响。方法选择104例肺心病患者，随机分为两组，对照组（常规治疗）和研究组（无创通气治疗），各52例。检测两组患者治疗前后的BNP水平，然后进行比较。结果治疗后两组血浆BNP水平均明显降低，且研究组血浆BNP水平为（197．8±39．6）ng/L，更低于对照组的（320．9±43．0）ng／L（t=3．22，P〈0．05）。结论无创正压通气治疗可以有效降低肺心病患者的BNP水平。

Objective To explore influence of noninvasive positive pressure ventilation treatment on the brain natriuretic peptide（BNP） level of patients with pulmonary heart disease. Methods 104 patients with pulmonary heart disease were randomly divided into two groups, control group （conventional therapy） and study groups （noninvasive ventilation）, each group 52 cases. The BNP level of the two groups before and after treatment were detected and compared. Results After treatment, the BNP level in the two groups were all decreased, and the BNP level of the study group was（ 197.8 ± 39.6）rig/L, which was significantly lower than that of the control group [ （320.9 ± 43.0）ng/L ] （t = 3.22,P 〈 0.05）. Conclusion Noni,vasive positive pressure ventilation treatment could effectively reduce BNP level in patients with pulmonary heart disease.