食道癌同期放化疗疗效分析

Efficacy of Concurrent Chemoradiotherapy for the Treatment of Patients with Esophageal Carcinoma

目的观察同期化放疗对食道癌的治疗效果。方法对2006年1月至2008年5月住院行同期放化疗治疗的28例食道癌患者和行序贯放化疗的23例食道癌患者进行对比研究,观察2种治疗方法的疗效及不良反应是否相同。结果同期放化疗组的总有效率为92.9%,序贯放化疗组的总有效率为69.6%,2组比较χ2=4.71,P=0.030<0.05;观察组的消化道反应和放射性食道炎显著高于对照组,但2组的WBC减少的比例、PLT减少的比例及肾毒性的发生率的差异没有统计学意义;2组1年生存率没有差异;同期放化疗组的2年和3年生存率均高于序贯放化疗组。结论虽然同期化放疗的消化道反应和放射性食道炎等毒副反应大,但其治疗有效率和患者生存率高,生存时间延长,是治疗食道癌的有效方法。

[Abstract] Objective To observe the efficacy of concurrent chemoradiotherapy for the treatment of patients with esophagealsame Carcinoma.Methods Compare the treatment effects and adverse reactions of 28 patients with esophagealsame Carcinoma who carried out concurrent chemoradiotherapy and 23 patients with esophagealsame Carcinoma who carried out sequential chemoradiotherapy.Resuits The overall effective （CR＋PR） rate in the concurrent group was 92.9%,in the sequential group was 69.6%χ^[2]=4.71,P=0.030〈0.05. The digestive tract and radiodermatitis rate of concurrent group were higher than sequential group, whereas WBC reduce proportion, PLT reduce proportion and incidence rate of renal toxicity were with no difference.The 2-year and 3-year survival rate of concurrent group were significantly higher than sequential group,whereas 1-year survival rate was with no difference.Conclusion Although the digestive tract and radiodermatitis rate of concurrent group were higher,the overall effective rate and survival rate were higher, survival time was significantly extended.So,the concurrent chemoradiotherapy was effective method to esophageal Carcinoma.