2010年山东省西部地区健康儿童麻疹、风疹、流行性腮腺炎免疫水平调查

Survey on Levels of Measles,Mumps and Rubella Antibodies Among Normal Children in the West of Shandong Province,2010

[目的]了解山东省西部地区健康儿童麻疹、风疹、流行性腮腺炎(腮腺炎)血清抗体水平。[方法]2010年11月,采集淄博、枣庄、莱芜、滨州、菏泽5市2～5岁、7～14岁健康儿童血标本,应用酶联免疫(ELISA)吸附法检测麻疹、风疹、腮腺炎IgG抗体。[结果]合计检测儿童661人,麻疹、风疹、腮腺炎抗体均阳性的415人,抗体阳性率为62.83%。麻疹、风疹、腮腺炎抗体阳性率分别为95.72%、75.82%、82.32%,GMC分别为1 086.93IU/ml、57.42IU/ml、79.79U/ml。麻疹抗体阳性率,2～5岁不同地区间麻疹抗体阳性率差异有统计学意义(P<0.05);风疹抗体阳性率,2～5岁组高于7～14岁(P<0.05),不同地区2～5岁、7～14岁儿童差异均有统计学意义(P<0.01);腮腺炎抗体阳性率,7～14岁高于2～5岁儿童(P<0.01),不同地区2～5岁、7～14岁儿童差异均有统计学意义(P<0.05)。[结论]山东省西部地区2～14岁儿童麻疹抗体水平较高。风疹、腮腺炎抗体水平较低,且地区间差别较大。

[Objective]To know antibody levels of measles, mumps and rubella in the west of Shandong province. [Methods]Serum specimens were collected from 2-5 and 7-14 years old children in Zibo, Zaozhuang, Laiwu, Binzhou and Heze cities,and IgG antibodies for measles, rubella,mumps were detected by ELSIA in November 2010. [Results]A total of 661 serum samples were detected. 415 （62.83%, 415/661 ） children＇s serum Samples were positive for measles, rubella,mumps IgG antibodies at the same time. The mean positive rates for measles, rubella, mumps were 95.720%, 75.82%, and 82.32%and geometric mean concentrations were 1 086.93 IU/ml, 57.42 IU/ml,and 79.79 U/ml respectively. There was statistical difference in measles positive rates among different areas in 2-5 years group（ P〈0.05）. Significant rubella pos- itive rates differences occurred between age groups （ P〈0.05,2-5 years group）7-14 years group） and different areas（ P〈0.01） and the similar statistical positive rates differences occurred in mumps .（ P 〈0. 05,2-5 years group〈7-14 years group; P d0.01, different districts）. [Conelusion]The measles IgG antibody levels are high in the west of Shandong prov- ince. However,rubella and mumps IgG antibody levels are low and vary in different areas.