通脉降脂软胶囊对大鼠高血脂症模型血脂的影响

EFFECTS OF TONGMAIJIANGZHI SOFT CAPSULE ON SERUM LIPID OF FATTY RATS

目的通脉降脂软胶囊对大鼠高血脂症模型血脂的影响。方法通过高脂饮食建立大鼠高血脂模型,设空白组、模型组、通脉降脂软胶囊低剂量组(低剂量组)、通脉降脂软胶囊中剂量组(中剂量组)、通脉降脂软胶囊高剂量组(高剂量组)、血脂康对照组,测定血清TC、TG、HDL、LDL、脂蛋白(LPα)、ALT及AST。结果空白组与模型组比较TG、LDL及血清脂蛋白(LPα)明显升高(P<0.05),各试验组与模型组TG比较明显降低(P<0.01),高剂量组TC与模型组的比较亦明显降低(P<0.05),高剂量组和血脂康对照组与模型组的LDL比较明显降低(P<0.01),各试验组对HDL作用不明显,各试验组和血脂康对照组对血清脂蛋白(LPα)无明显影响,各试验组与空白对照组的ALT、AST比较差异无统计学意义。结论通脉降脂软胶囊量具有降低高血脂大鼠血脂的作用,对肝功能没有显著影响。

Objective To observe the effects of TongmaiJiangzhi soft capsule（TSC） on hyperlipemia rats＇models of blood fat.Methods The hyper lipid model was established by giving high fat diet to the rats.They were randomly divided into normal control group,model group,low,middle and high dosage TSC groups,Xuezhikang control group.The level of TC、TG、HDL、LDL、LPα、ALT and AST of serum was determined.Results Compared with normal control group,TC、TG、LDL and LPαwere higher in the model group（P0.05）.The level of TC was clearly decreased in the other groups than that in model group（P0.01）,but it was obviously higher in the model group than high-dosage group,（P0.01）.Compared with high-dosage group,LDL was obviously higher in the model group and Xuezhikang control group（P0.01）.There＇s less effect on HDL in all test groups,and so as LPα.There＇s no statistically significance between normal group and others about their ALT or AST.Conclusion Tongmaijiangzhi soft capsules could decrease the level of serum lipid of fatty rats,but there＇s no significant effect on liver function.