人工合成抗菌肽的常用方法及应用前景

The common methods and application prospect of the artificial synthetic antibacterial peptide

抗菌肽是来自生物体内经诱导产生的一种具有抗菌活性的小分子多肽,能够高效杀灭多种革兰阴性、阳性菌,其作为抗生素的替代品,能有效解决耐药性等问题。由于天然产生的抗菌肽数量较少,往往很难大量获得,而通过人工合成方法,可解决表达量和所需成本等问题,也可在一定程度上进行抗菌肽抑菌功能上的改进。本文综述了人工合成抗菌肽的常用方法与研究进展,探讨了人工合成抗菌肽在未来的应用前景。

Antibacterial peptides, generated by induction in vivo, are small molecular polypeptides with antimicrobial activity. As an alternative to antibiotics, antibacterial peptides are able to sterilize the Gram-negative or Gram-positive bacteria effectively, solving the problem of drug resistance. Generally, it is rather difficult to obtain a large number of antibacterial peptides due to the small number of naturally produced antibacterial peptides. To resolve such issues as expression or cost, the methods of artificial synthetic was adopted, for which the improvement on the antibacterial peptides＇ function to some extend is possible. This paper summarized some common methods and research progress of the artificial synthetic antibacterial peptides and discussed the application prospect in the future.