摘要
我们调查了化纤厂女工接触丙烯腈与丙烯酸甲酯后与自然流产发生的关系。196名接触者为暴露组,151名未接触者为对照组。自然流产发生率各为13.2％与2.96％,P<0.001,RR=4.5。夫妻双方均暴露于毒物者,自然流产率为20.8％,明显高于单方暴露者。如女方暴露,其丈夫吸烟,可增加自然流产发生的危险性,呈现一个正交互作用。
An investigation of relationship between acrylonitrile(AN), Methyl acrylate(MA) and spontaneous abortion was carried out in Fushun Chemical Fibre Factory. 196 women who had at least one year of occupational exposure to AN, MA,and 151 women who had never exposed to AN, MA were interviewed about their history of spontanous abortion. The rate of spontaneous abortion of exposed and nonexposed women were 13.2％ and 2.96％ respectively (p<0.01). An interesting interaction of risk was noted for some couples. Couples where the women exposed to AN and MA, and their husbands exposed to the same toxicant or were cigarette smokers had a high rate of spontaneons abortion, 20.80％ and 16.67％ respectively. The results suggested that AN, MA may be the risk factors for developmenf of spontaneous abortion. Cigarettes smoking did not show as an independent risk for spontaneous abortion, but the two combination of smoking and AN, MA showed an interaction to it.
