摘要
目的:研究中华雪胆化学成分。方法:应用色谱技术进行分离和纯化,采用UV,IR,MS,NMR等波谱技术鉴定结构。结果:从中华雪胆中分到8个三萜类化合物,分别为23,24-二氢葫芦素B(1),23,24-二氢葫芦素F-25-乙酸酯(2),葫芦素F(3),3-O-(6'-乙酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-α-L-吡喃阿拉伯糖苷(4),齐墩果酸-3-O-(6'-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-3)-α-L-吡喃阿拉伯糖苷(5),齐墩果酸-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖苷(6),3-O-(6'-甲酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-β-D-吡喃葡萄糖基-(1-6)-β-D-吡喃葡萄糖苷(7),3-O-(6'-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-2)-β-D-吡喃葡萄糖基-齐墩果酸-28-O-β-D-吡喃葡萄糖苷(8)。结论:除化合物2外,其余化合物均是首次从中华雪胆中分离得到。
Objective: To study the chemical constituents of Hemsleya chensnsis. Method: Various chromatographic techniques were used to separate and purify the constituents. The spectral data (MS, NMR) were obtained for structure elucidation. Result: Eight known triterpenoid saponins were isolated from the root of H. chensnsis. Their structures were elucidated as dihydrocucurbitacin B (1), 25-O-acetyl-dihydrocucurbitacin F (2), cucurbitacin F (3), 3-O-(6'-ethyl ester)-β-D-glucuropyranosyl oleanolic acid-28-O-α-L-arabinopyranoside ( 4 ) , oleanolic acid-3 - ( 6'-methyl ester) -β-D-glucuropyranosyl ( 1-3 ) -α-L-arabinopyranoside ( 5 ), oleanolic acid-28 -O- β-D-glucopyranosyl- ( 1-6 ) -/3-D-glucopyranoside ( 6 ), 3-O- ( 6 '-methyl ester ) -β-O-glucuropyranosyl oleanolic acid-28-O-β-D-glucopyr- anosyl- ( 1-6 ) -β-D-glucopyranoside ( 7 ), 3 -O- ( 6'-methyl ester) -β-D-glucuropyranosyl ( 1-2 ) -β-D-glucopyranoside-oleanolic acid-28-O- β-D-glucopyranoside (8). Conclusion: All compounds except for 2 were isolated from 11. chensnsis for the first time.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第6期814-817,共4页
China Journal of Chinese Materia Medica
基金
温州医学院校人才科研启动基金项目(2004-127)
关键词
中华雪胆
化学成分
Hemsleya chensnsis
chemical components