中华雪胆化学成分研究(Ⅲ)

Chemical Components in Hemsleya chensnsis(Ⅲ)

目的:研究中华雪胆化学成分。方法:应用色谱技术进行分离和纯化,采用UV,IR,MS,NMR等波谱技术鉴定结构。结果:从中华雪胆中分到8个三萜类化合物,分别为23,24-二氢葫芦素B(1),23,24-二氢葫芦素F-25-乙酸酯(2),葫芦素F(3),3-O-(6'-乙酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-α-L-吡喃阿拉伯糖苷(4),齐墩果酸-3-O-(6'-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-3)-α-L-吡喃阿拉伯糖苷(5),齐墩果酸-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖苷(6),3-O-(6'-甲酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-β-D-吡喃葡萄糖基-(1-6)-β-D-吡喃葡萄糖苷(7),3-O-(6'-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-2)-β-D-吡喃葡萄糖基-齐墩果酸-28-O-β-D-吡喃葡萄糖苷(8)。结论:除化合物2外,其余化合物均是首次从中华雪胆中分离得到。

Objective： To study the chemical constituents of Hemsleya chensnsis. Method： Various chromatographic techniques were used to separate and purify the constituents. The spectral data （MS, NMR） were obtained for structure elucidation. Result： Eight known triterpenoid saponins were isolated from the root of H. chensnsis. Their structures were elucidated as dihydrocucurbitacin B （1）, 25-O-acetyl-dihydrocucurbitacin F （2）, cucurbitacin F （3）, 3-O-（6＇-ethyl ester）-β-D-glucuropyranosyl oleanolic acid-28-O-α-L-arabinopyranoside （ 4 ） , oleanolic acid-3 - （ 6＇-methyl ester） -β-D-glucuropyranosyl （ 1-3 ） -α-L-arabinopyranoside （ 5 ）, oleanolic acid-28 -O- β-D-glucopyranosyl- （ 1-6 ） -/3-D-glucopyranoside （ 6 ）, 3-O- （ 6 ＇-methyl ester ） -β-O-glucuropyranosyl oleanolic acid-28-O-β-D-glucopyr- anosyl- （ 1-6 ） -β-D-glucopyranoside （ 7 ）, 3 -O- （ 6＇-methyl ester） -β-D-glucuropyranosyl （ 1-2 ） -β-D-glucopyranoside-oleanolic acid-28-O- β-D-glucopyranoside （8）. Conclusion： All compounds except for 2 were isolated from 11. chensnsis for the first time.