体力活动减弱FTO基因遗传变异对体重指数及腰围增加的影响

Physical Activity Attenuates the Impact of FTO Variant on Body Mass Index and Waist Circumference

目的：通过对不同人群开展遗传与体质状况的研究，探讨基因多态变化与BMI（体重指数）和WC（腰围）的关系；并在此基础上研究不同体力活动水平的人群FTO基因多态的变化对BMI和WC的影响，旨在对了解遗传与环境交互作用对体质状况的影响以及拓展体质健康研究领域。方法：对来自于中国北方地区汉族人群中20774例FTO基因变体为r1121980的受试者（年龄39-79岁之间）进行基因分型（受试者均来自于同一个种族人群）。采用调查问卷评估体力活动（PA）。通过数理统计分析来检查rs1121980和体力活动之间的相互作用对体重指数和腰围（WC）的影响。结论：rs1121980风险等位基因（T）与体重质指数和腰围具有非常显著的相关性（P〈0．001）；体力活动减弱了rs1121980对体重指数和腰围的影响。该研究结果具有重要的公共卫生学意义，研究表明由FTO基因变异诱导的肥胖遗传易感性可以通过进行体育活动的生活方式来解决。

Objective： This study was carried out on different populations of genetic and physical conditions to con- fer the relationship between genetic polymorphisms and the body mass index （BMI） and waist circumference （WC）. And on this basis, this study observes the impact of the changes of FTO gene polymorphism of people with different levels of physical activity on the body mass index （BMI） and waist circumference （WC）, so as to understand the interaction of genetic and environmental effects on physical condition, and provide theoretical guidance of developing physical health research. Method： The FTO variant rs1121980 was genotyped in 20,774 participants （39-79 y of age） from the Han population in Northern China, an ethnically homogeneous popula- tion based cohort physical activity （PA） was assessed with a validated self reported questionnaire. The interaction between rs1121980 and PA on body mass index （BMI） and waist circumference （WC） was examined by includ- ing the interaetion term in mixed effect models. Result： It confirmed that the risk （T） allele of rs1121980 was significantly associated with BMI and WC. The PA level attenuated the effect of rs1121980 on body mass index （BMI） and waist circumference （WC） ; Conclusion： the results showed that PA attenuates the effect of the FTO） rs1121980 genotype on body mass index （BMI） and waist circumference （WC）. This observation has important public health implications because it shown that a genetic susceptibility to obesity induced by FTO variation can be overcome, at least to some extent, by adopting a physically active lifestyle.