FOXC2-512 C>T基因多态性与蒙古族代谢综合征患者血脂的相关性研究

A Correlative Study of FOXC2-512C>T Gene Polymorphism and Serum Lipids in Mongolian People with Metabolic Syndrome

目的:在内蒙古包头地区蒙古族人群中,探讨FOXC2-512 C>T基因多态性与代谢综合征(metabolic syn-drome,MS)患者血脂的相关性,为MS的早期诊断及预防提供实验依据。方法:在MS患者中,采用等位基因序列特异性聚合酶链反应法(PCR-SSP)检测FOXC2-512 C>T基因多态性,并比较不同基因型间甘油三酯(TC)、胆固醇(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平差异,分析FOXC2-512 C>T多态性与MS患者血脂的关系。结果:检测的各指标在CC、CT、TT三种基因型间的差异均无统计学意义。结论:FOXC2-512 C>T基因多态性与蒙古族代谢综合征患者的血脂没有关联。

Objective: To investigate the correlation of FOXC2-512C>T gene polymorphism with serum lipids in Mongolian people with metabolic syndrome(MS)so as to provide a scientifically experimental basis for early diagnosis,treatment and prevention of MS.Methods: FOXC2-512C>T gene polymorphism was examined by allele-specific polymerase chain reaction sequence(PCR-SSP),with level differences in triglycerides(TC),cholesterol(TG),low density lipoprotein(LDL),high density lipoprotein(HDL) compared among different genotypes.The correlation of FOXC2-512C>T polymorphism with dyslipidemia in MS patients was analyzed as well.Results: There was no significant difference in all determination indicators discussed above among the three genotypes groups of C/C,T/T,T/C.Conclusion: FOXC2-512C>T gene polymorphism is not correlated with dyslipidemia in Mongolian MS patients.