慢性乙型重型肝炎309例中医证型与预后关系研究

Research of the relationship between different traditional Chinese medicine syndromes and prognosis in 309 chronic severe hepatitis B

目的通过对309例不同中医证型的早中期慢性乙型重型肝炎中西医结合治疗的临床回顾性研究,探讨不同中医证型与预后之间的关系。方法所有患者均在中医辨证基础上进行常规中西医结合治疗,包括保肝、退黄、抗病毒、对症支持及辨证中药治疗,对其预后进行统计分析。结果 309例患者治疗总有效率65.0%,无效率35.0%;不同中医证型组间疗效不同,湿热发黄证组与瘀热发黄证组疗效较好,优于气虚瘀黄证组与复合证型组(P<0.05)。结论不同中医证型慢性乙型重型肝炎患者预后不同,以中医证型预测患者预后有一定科学性。

Objective To explore the relationship between different Chinese traditional medicine syndromes and prognosis through retrospective analysis of 309 early-mid stage chronic severe hepatitis B patients with various traditional Chinese medicine syndromes.Methods All cases were treated by routine integrated traditional and western medicine,including hepatocytes-protection,jaundice-relieving,antivirus,support care and Chinese herbs based on differentiation of syndromes.Results The total effective rate was 65.0%,the ineffective rate was 35.0%.There were different efficacies in different syndromes,groups of hygropyretic jaundice and heat-stagnant jaundice got better effects than groups of Qi-deficiency jaundice and compound syndrome（P0.05）.Conclusion There are different prognoses in different syndromes of chronic severe hepatitis B,it is scientific that traditional Chinese medicine syndromes are used to predict the prognosis.