肝硬化失代偿患者血尿酸水平的变化及意义

Clinical significance of serum uric acid in patients with decompensated cirrhosis

目的探讨肝硬化失代偿患者血尿酸(UA)水平的变化及意义。方法应用酶法测定81例肝硬化失代偿患者和32例健康对照者血UA值,并计算其肾小球率过滤(GFR)。结果肝硬化失代偿组、肝功能各分级组、腹水组的UA值与健康对照组比较,均无统计学差异;肝硬化失代偿患者GFR水平分组的UA值与健康对照组比较,有统计学差异。结论肝硬化失代偿患者血尿酸水平与肝功能损害程度无明显关系,尿酸水平不能作为判断肝硬化失代偿患者腹水程度的指标,UA水平可在一定程度上反映肝硬化失代偿患者肾功能的变化。

Objective To explore the variation and clinical significance of serum level of uric acid in patients with decompensated cirrhosis.Methods The serum level of UA was measured by enzymatic method in 81 patients with hepatocirrhosis at the stage of decompensation and 32 health controls,and their GFR was calculated.Results There was no significant difference in serum levels of UA between patients with decompensated hepatocirrhosis or with ascites and healthy controls.The statistical difference in serum level of UA in GFR based grouping between decompensated cirrhosis and healthy controls was significant.Conclusion There was no significant relationship between serum level of UA and degree of impairment of liver function in patients with decompensated hepatocirrhosis.The serum level of UA can not be applied as an indicator for determining the severity of ascites in patients with hepatocirrhosis.The serum level of UA reflects the change in renal function of patients with decompensated hepatocirrhosis.