磷脂酶Cγ的分子生物学研究进展

The study progress in molecular biology of PLCγ

磷脂酶Cγ（PLCγ）是磷脂酶C（PLC）的一种，而磷脂酶C又是磷脂酰肌醇信号通路的关键酶，在机体内分布极为广泛。许多细胞外因子，如细胞表面抗原、免疫球蛋白、细胞因子、生长因子等都可以借助PLC的生化途径激活磷脂酰肌醇特异性途径作用于细胞，调控细胞代谢。PLCγ在B淋巴细胞的整个发育过程以及在其他生命活动中都起着重要的作用。

Phospholipase Cγ（PLCγ） is one of the phospholipase C （PLC） which is the key enzymes of phosphatidylinositol signaling pathway. PLC is widely distributed in the body. Many extracellular factors, such as cell surface antigen, immunoglobulin, cytokines, growth factors function through PLC signaling pathway. PLC plays an important role during the whole process of B lymphocyte development and other life activities.