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多发性硬化治疗药物新进展 被引量:1

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摘要 多发性硬化(multiple sclerosis,MS)作为一种中枢神经系统脱髓鞘自身免疫性疾病,它的特点为神经系统进行性的功能丧失,发病原因多为轴突的永久性损伤,其临床表现具有多样性,可以导致躯体和认知上的症状及体征,如感觉虚弱与易疲劳、共济失调、躯体功能障碍、膀胱及肠道问题、感觉障碍以及视力缺损等情况,并且受感染、环境、气候以及其他因素的影响。
出处 《国际免疫学杂志》 CAS 2012年第2期163-164,共2页 International Journal of Immunology
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  • 1李海峰,魏岗之.多发性硬化治疗进展[J].国际神经病学神经外科学杂志,2007,34(2):103-108. 被引量:5
  • 2SAFA VIZADEH N , RAHMANI SA, ZAEFIZADEH M. Investi- gation of cytocrom c oxidase gene subunits expression on the Multiple sclerosis [J]. Indian J Hum Genet, 2013 , 19 ( 1 ) : 18-25.
  • 3SUMOWSKI J F, LEA VITI V M. Cognitive reserve in multiple sclerosis [J]. Mult Scler ,2013 , 19 (9) : 1122-1127.
  • 4MCCOYD M. Update on therapeutic options for multiple sclerosisj f]. Neurol Clin,2013,31(3) :827-845.
  • 5BATES D. Treatment effects of immunomodulatory therapies at different stages of multiple sclerosis in short- term trials [J] . Neurology,2011 ,76(1 Suppl1) :514-S25.
  • 65TYS P K, ZAMPONI G W , van MINNEN J, et al. Will the real multiple sclerosis please stand up? [J]. Nat Rev Neurosci, 2012,13 (7) :507-514.
  • 7CHENG X J, XU L Z. Review of the diagnosis and clinical features of multiple sclerosis in China [J]. Neurosci Bull, 2009, 25 (1) :3~-42.
  • 8HYLAND M, RUDICK R A. Challenges to clinical trials in multiple sclerosis: outcome measures in the era of diseasemodifying drugs [J]. CUIT Opin Neurol, 2011 , 24 ( 3 ) : 255-261.
  • 9EDAN G, MILLER D, CLANET M, et al. Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria [J]. J Neurol Neurosurg Psychiatry, 1997,62(2) :112-118.
  • 10HARTUNG H P , GONSETIE R,KONIG N ,et al. Mitoxantro- ne in progressive multiple sclerosis: a placebo- controlled, double- blind, randomised, multi centre trial [J]. Lancet, 2002,360(9350) :2018-2025.

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