溪桫化学成分研究

Chemical constituents of Chisocheton cumingianus

目的:研究楝科溪桫属植物溪桫[Chisocheton cumingianus subsp.balansae(C.Candolle)Mabber-ley]的小枝及茎皮化学成分。方法:利用正相、反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱、制备HPLC等方法分离化合物,运用MS和NMR等波谱方法解析鉴定化合物结构。结果:从其乙醇提取物之三氯甲烷萃取部位中分离鉴定出10个化合物,分别为4个三萜类化合物:odoratone(1),grandifoliolenone(2),24-表-匹西狄醇A(24-epi-piscidinol A,3),chisiamol F(4);3个倍半萜类化合物:1β,6α-二羟基-4(15)-桉叶烯(1β,6α-dihydroxy-4(15)-eudesmene,5),1β,8α-二羟基-4(15)-桉叶烯(1β,8α-dihydroxy-4(15)-eudesmene,6),环氧泽泻烯(alismoxide,7);3个蒽醌类化合物:大黄酚(8),大黄素(9),大黄素甲醚(10)。结论:10个化合物均首次从该植物中分离得到。

Objective： To determine the chemical constituents of the twigs of Chisocheton cumingianus subsp.balansae（C.Candolle） Mabberley.Methods： To isolate the compounds,column chromatography,such as silica gel,Sephadex LH-20,C18 reverse-phased silica gel,and preparative HPLC were used.Spectroscopic methods like MS,1H and 13C NMR were used to elucidate the structures of the isolated compounds.Results： Ten compounds were isolated and elucidated as 4 triterpenes,namely odoratone（1）,grandifoliolenone（2）,24-epi-piscidinol A（3）,and chisiamol F（4）,3 sesquiterpenes,which was 1β,6α-dihydroxy-4（15）-eudesmene（5）,1β,8α-dihydroxy-4（15）-eudesmene（6）,and alismoxide（7） and 3 anthraquinone,including chrysophanol（8）,emodin（9）,and emodin monomethyl ether（10）.Conclusion：All compounds were isolated from Chisocheton cumingianus subsp.balansae（C.Candolle） Mabberley for the first time.