氧化脱肟研究新进展

Recent Advances in Oxidative Deoximation

肟是有机合成中一类非常重要且常见的化合物,不仅可用作羰基化合物的保护,而且可通过肟化-脱肟过程对羰基化合物进行分离和纯化。此外,肟还可以由非羰基化合物转变而来,进而通过脱肟反应生成羰基化合物,因此,如何在温和条件下高效实现脱肟反应吸引了人们的广泛关注。目前,已报道的脱肟方法主要包括酸性水解、氧化、还原等。其中,氧化脱肟法,特别是利用过氧化氢或氧气作氧化剂的绿色氧化脱肟方法尤受重视。本文以此为重点,综述了近年来氧化脱肟方法的研究概况和最新进展,并对若干重要的体系作了详细讨论。

Oximes are extensively used as preferred derivatives for protection, purification and characterization of carbonyl compounds as well as a valid alternative pathway to prepare carbonyl compounds. Therefore, there has been a continued interest in the development of procedures like hydrolysis, reduction, oxidation for the effective regeneration of carbonyl compounds. Among them, the oxidative deoximation has attracted much attention currently. In this paper, the recent progress in oxidative deoximation, especially in utilizing hydrogen peroxide and oxygen as the green oxidants, are discussed in detail.