阿德福韦酯联合双环醇治疗慢性乙型肝炎疗效分析

目的：阿德福韦酯联合双环醇治疗慢性乙型肝炎的疗效。方法：选择71例轻中度慢性乙型肝炎患者随机分为2组接受试验，试验组36例，每日口服阿德福韦酯（山东鲁抗辰欣生产，商品名丁贺，以下简称丁贺）10mg，同时每13Et服双环醇（北京协和生产）150mg，对照组35例，仅给予每日口服丁贺10mg，2组均连续用药48周，观察治疗前后血清氨基转移酶水平及病毒学标志方面的改变；结果：2组血清氨基转移酶均得到明显下降，试验组更为显著（P〈0．05）。试验组HBVDNA转阴率（47．2％）显著高于对照组（31．4％），P〈0．05，试验组HBeAg转阴率（33.3％）及HbeAg血清转换率（25．7％）虽高于对照组（19．4％，14．3％），但差异无统计学意义。结论：丁贺与双环醇联合应用治疗慢性乙型肝炎在肝功能学方面取得较好疗效。

Objective： adefovir dipivoxil joint bicyclol treatment of chronic hepatitis b curative effect. Methods selection 71 cases mild-to-moderate chronic hepatitis b patients were randomly divided into two groups, to the test group （36 cases） and daily oral adefovir dipivoxil （shandong LuKang Calvin bin, commodity production DingHe, hereinafter referred to as the ＂name, and DingHe） 10rag daily oral bieyclol （Beijing union production）, the control group 35 examples, 150mg per DingHe 10mg only give oral medication, two groups are continuous, 48 weeks observed before and after treatment serum amino transferase level and virology sign of change; Results 2 groups of serum amino transferase both will be housed declined obviously, and more significantly （P 〈 0.05）. 4.75%more HBV DNA, shade rate was significantly higher than the control group （47.2%） （31.4%）, P 〈 0.05 group a, turn rate HBeAg HBeAg serum （33.3%） and conversion （25.7%） is higher than that of the control group （19.4%, 14.3%）, but the difference was not statistically significant. Conclusion DingHe and bicyclol combined application in the treatment of chronic hepatitis b liver learning has good curative effect.