摘要
肠易激综合征(IBS)是最常见的功能性胃肠病之一,已有研究证据表明其可能是多种因素共同作用的结果,包括遗传和环境因素、胃肠动力改变、内脏高敏感、肠道感染和炎症、慢性应激、肠道细菌过度生长和脑-肠轴功能紊乱等。部分患者在急性肠道感染恢复后仍存在腹痛、腹部不适、腹泻等症状,即感染后肠易激综合征(PI-IBS),是近年功能性胃肠病的研究热点。本文就PI-IBS的定义、流行病学、发病机制、动物模型、临床特征、诊断和治疗等研究现状作一概述。
Irritable bowel syndrome（IBS） is one of the most common functional gastrointestinal disorders.Existing evidences indicate that IBS is the result of concurrent effects of multiple factors,including genetic and environmental factors,altered gastrointestinal motility,visceral hypersensitivity,intestinal infection and inflammation,chronic stress,enteric bacteria overgrowth and dysregulation of brain-gut axis,etc.Some patients may have persistent symptoms such as abdominal pain,abdominal discomfort and diarrhea after the recovery of acute intestinal infection and this is defined as post-infectious irritable bowel syndrome（PI-IBS）,which is a hotspot of study on functional gastrointestinal disorders in recent years.This article reviewed the current status of study on the definition,epidemiology,pathogenesis,animal model,clinical feature,diagnosis and treatment of PI-IBS.
出处
《胃肠病学》
2012年第2期71-74,共4页
Chinese Journal of Gastroenterology
关键词
肠易激综合征
感染
发病机制
模型
动物
Irritable Bowel Syndrome
Infection
Pathogenesis
Models
Animal
