摘要
丝氨酸/苏氨酸蛋白激酶即蛋白激酶B(protein kinase B,PKB/Akt)是细胞内最重要的激酶之一,它能够通过接受整合多种细胞外信号产生多种生物学效应,包括对细胞增殖、迁徙、生长、周期、能量代谢、死亡等多方面的影响。Akt在乳腺癌发展过程中的作用成为研究热点。现就近两年来Akt与乳腺癌的重要研究成果予以综述。
The protein serine/threonine kinase Akt,also known as protein kinase B(PKB),is one of the most important kinases in cell.Akt integrates a plethora of extracellular signals to generate diverse outcomes,including proliferation,motility,growth,cell cycle,glucose homeostasis,and cell death.What is the role of Akt in the breast cancer has become a research focus.In this review,we will show the most important and latest research about Akt with breast cancer.
出处
《现代肿瘤医学》
CAS
2012年第3期622-624,共3页
Journal of Modern Oncology
基金
重庆市科技攻关项目(编号:CSTC
2008AC5082)