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N-乙酰半胱氨酸联合维生素C预防造影剂对肾功能不全患者所致肾损害 被引量：1

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摘要 目的:探讨N-酰半胱氨酸(NAC)与维生素C对中、重度肾功能不全患者造影剂肾病(CIN)的预防作用方法:108例中、重度肾功能不全患者随机分为三组,分别接受0.9%氯化钠溶液(对照组,33例),NAC加0.9%氯化钠溶液(NAC组,34例),以及NAC、维生素C加0.9%氯化钠溶液(NAC+维C组,41例)三种预防方案;所有患者均使用碘克沙醇造影剂。记录患者术前24 h与术后24 h～48 h内血清肌酐(SCr)、尿素(UREA)及尿酸(UA)浓度。结果:三组患者术前与术后的SCr、UREA以及UA值比较差异无统计学意义;三组术后的SCr、UREA以及UA值比较,差异无统计学意义;三组患者肾病发生率比较,差异无统计学意义。结论:NAC与维生素C对造影剂肾病无预防作用。
作者 王伟巍 吴玉波 李岩 徐艳丽 蒋爱华 孙向菊
机构地区 哈尔滨医科大学附属第四临床医院药学部
出处 《药物流行病学杂志》 CAS 2012年第2期62-63,70,共3页 Chinese Journal of Pharmacoepidemiology
关键词 乙酰半胱氨酸 维生素C 肾功能不全 造影剂
分类号 R692.5 [医药卫生—泌尿科学]
  • 相关文献

参考文献14

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二级参考文献8

共引文献3

同被引文献32

  • 1扆恒亮,谭宁,邓宇珺.N-乙酰半胱氨酸和碳酸氢钠预防中重度肾功能不全患者对比剂肾损害的作用[J].岭南心血管病杂志,2009,15(5):347-349. 被引量：4
  • 2丁晓隽,李慧华.急性冠状动脉综合征患者介入治疗中N-乙酰半胱氨酸对造影剂相关性肾病保护作用的临床研究[J].中华临床医师杂志（电子版）,2011,5(15):4499-4501. 被引量：3
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引证文献1

二级引证文献7

药物流行病学杂志
2012年 第2期

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