2Kim KW,Wang Z,Busby J,et al.The role of tyrosine 177 in human11beta-hydroxysteroid dehydrogenase type 1 in substrate and in-hibitor binding:an unlikely hydrogen bond donor for the substrate[J].Biochim Biophys Acta,2006,1764:824-830.
3Shafqat N,EllebyB,Svensson S,et al.Comparative enzymologyof 11beta-hydroxysteroid dehydrogenase type 1 from glucocorticoid resis-tant(Guinea pig)versus sensitive(human)species[J].J Biol Chem,2003,278:2030-2035.
4Wasilewska A,Zoch-Zwierz W,Pietruczuk M,et a1.Expression ofP-glycoprotein in lymphocytes from children with nephrotic syn-drome,depending on their steroid response[J].Pediatr Nephrol,2006,21:1274-1280.
6YangXY,Xu DH.MDR1(ABCB1)gene polymorphisms associatedwith steroid-induced osteonecrosis of femoral head in systemic lupuserythematosus[J].Pharmazie,2007,62:930-932.
8Jiang T,Liu S,Tan M,et al.The phase-shift mutation in the gluco-corticoid receptor gene:potential etiologic significance of neuroen-docrine mechanisms in lupus nephritis[J].Clin Chim Acta,2001,313:113-117.
9Lee YM,Fujiwara J,Munakata Y,et al.A mutation of the glucocorti-coid receptor gene in patients with systemic lupus erythematosus[J].Tohoku J Exp Med,2004,203:69-76.
10Charmandari E,Kino T,Ichijo T,et al.A novel point mutation inhelix 11 of the ligand-binding domain of the human glucocorticoidreceptor gene causing generalized glucocorticoid resistance[J].J ClinEndocrinol Metab,2007,92:3986-3990.
3Pratt W B, Toft D O. Steroid receptor interactions with heat shock protein and immunophilin chaperones [J]. Endocr Rev, 1997,18(3):306-360.
4Denis M, Gustafsson j A. The Mr approximately 90000 heat shock protein : an important modulator of ligand and DNA-binding properties of the glucocorticoid receptor [J]. Cancer Res, 1989 , 49(8 Suppl) :2275-2281.
5Vachier I, Chiappara G, Vignola A M et al. Glucocorticoid receptors in bronchial epithelial cells in asthma [J]. Am J Respir Crit Care Med, 1998, 158(3):963-970.
6Czar M J, Galigniana M D, Silverstein A M et al.Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus [J]. Biochemistry, 1997,36(25):7776-7785.
7Liu J, DeFranco D B. Chromatin recycling of glucocorticoid receptors: implications for multiple roles of heat shock protein 90 [J]. Mol Endocrinol, 1999, 13(3) : 355-365.
8Haack D, Scharer K, Asam T A et al. Glucocorticoid receptors in idiopathic nephritic syndrome [J]. Pediatr Nephrol, 1999, 13 (8):653-656.
9Kaufmann S H. Heat shock proteins and immune response [J]. Immunol Today, 1990, 11(4):129-136.
10Kang K I, Meng X, Devin-Leclcre J et al. The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter [J]. Proc Natl Acad Sci USA, 1999,96(4):1439-1444.
6Buttgereit F,da Silva JA,Boers M. Standardised nomencla ture for glucocorticoid dosages and glucocorticoid treatment regi mens:current questions and tentative answers in rheumatolo gy[J].Annals of the Rheumatic Diseases,2002,(08):718-722.
7Badsha H,Kong KO,Lian TY. Low-dose pulse methyl prednisolone for systemic lupus erythematosus flares is effica cious and has a decreasedrisk of infectious complications[J].Lupus,2002,(08):508-513.
8Xuc L, Li C,Wang Y, et al. Single nucleotide polymorphisms in non- coding region of the glucocorticoid receptor gene and prednisone re- sponse in childhood acute lymphoblastic leukemia [J].Leuk Lympho- ma,2015,56(6) : 1704-1709.
9Panek M, Pietras T, Fabijan A, et al. The NR3C1 glucocorticoid re- ceptor gene polymorphisms may modulate the TGF-beta mRNA ex- pression in asthma patients [J].lnflamnmtion, 2015,38 ( 4 ) : 1479- 1492.
10Chen IlL, Li LIl. Glucoeortieoid receptor gene polymorphisms and glu- cocollicoid resistance in inflammatory bowel disease: a meta-analysis [ J ]. Dig Dis Sci ,2012,57 ( 12 ) :3065-3075.
