摘要
具有重要里程碑意义的Massachusetts老年男性研究结果让我们对勃起功能障碍fED）的发病有了新的理解，同时也让我们认识到ED是一种老龄化疾病。在过去很多年里，ED已经在一些患者中被认为与心血管疾病（CVD）的形成有关。也有证据显示ED与CVD有共同和类似的风险因子。CVD是最容易鉴别的死亡原因之一。预防cVD引发死亡的早期筛查也成为许多学者热捧的领域。因此，很多学科都对“ED是否可以作为CVD的标志”这一提案产生了浓厚的兴趣。事实上，已经有了一些将ED用作CVD发病筛查工具的提案。因此，本文在两个主要数据库中（Pubmed和Cochrane library）进行了全面检索。关键词为：急性心肌梗塞（AMI），冠状动脉疾病（CAD）和勃起功能障碍（ED）。本文浏览了2000年1月至2011年6月期间发表的所有讨论ED和cVD关系的英文文章。对包括所有相关的随机对照试验，队列以及回顾性研究，综述进行分析，以探讨是否所有ED患者应该进行CVD的临床评估。结果显示，在一些患者中，ED与将来CVD的发病有关，但ED不是一个独立的，比传统的Framingham风险因子更好的预测因子。然而，这样的CVD筛查对于患有严重ED的年轻患者以及同时有其他CVD风险因素的患者是有好处的。
The landmark Massachusetts Male Ageing Study shed new light on the prevalence of erectile dysfunction （ED） and drew attention to ED as a disease of ageing. Over the years, ED has been linked to the development of cardiovascular disease （CVD） in some patients. There is clear evidence that ED and CVD share and have a similar risk factor profile. CVD is one of the most recognizable causes of mortality and early detection coupled with prevention of mortality from CVD has been the prime interest of many researchers. Consequently, there has been a multidisciplinary curiosity regarding the proposal to use ED as a marker for future CVD. I n fact, there have been several proposals to use ED as a screening tool for future CVD. We performed a comprehensive Search of two main databases--PubMed and Cochrane Library using a combination of keywords such as acute myocardial infarction, coronary artery disease （CAD） and ED. Journal articles from January 2000 to June 2011 were reviewed. We included all articles discussing the relationship between ED and CVD in the English language. All the relevant randomized controlled trials, cohort and retrospective studies, and review articles were included in our overall analysis in an attempt to answer the question whether all patients with ED should be clinically evaluated for CVD. The results showed a link between ED and the development of future CVD in some patients, but ED was not shown to be an independent risk predictor that is any better than the traditional Framingham risk factors. Screening for CVD may, however, be rewarding in younger patients with severe ED and in patients with concurrent CVD risk factors.
