摘要
阴茎异常勃起是指阴茎在没有受性刺激的情况下,发生的不自主的长时间勃起。目前,关于这种异常勃起的病理生理学信息很少,所以我们对此疾病也知之甚少。这种不可逆的勃起伤害以及导致的勃起功能障碍使这种疾病的并发症也很可怕。间歇性阴茎异常勃起尽管很少见,但在镰状细胞疾病(SCD)患者中发生率很高,而且也迫切需要制定指南来治疗这些病人的勃起功能问题。因为对这种疾病的发病机制不是很清楚,所以对泌尿外科医生来说,这种疾病的药物治疗也是一个极大的挑战。还需要更多的研究让我们可以有效确定这些病人的治疗方法,以预防作为最终目的。本综述主要介绍间歇性阴茎异常勃起疾病及其临床意义,尤其针对那些有SCD的病人。另外,还讨论该疾病可能的病理生理学机制,总结和讨论当前和将来的药物治疗策略。
Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction (ED). Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease (SCD) and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.