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Another road leads to HIF-1 activation： implications for prostate cancer progression

Another road leads to HIF-1 activation： implications for prostate cancer progression
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摘要 Hypoxia has been identified as a common environmental stress factor associated with therapeutic resistance and metastasis in human cancers. A major player in regulating the response to hypoxia is the transcriptional factor hypoxia-inducible factor 1 alpha （HIF-1α）. Hypoxia has been identified as a common environmental stress factor associated with therapeutic resistance and metastasis in human cancers. A major player in regulating the response to hypoxia is the transcriptional factor hypoxia-inducible factor 1 alpha （HIF-1α）.
作者 Yao Dai Kyungmi Bae Dietmar W Siemann
机构地区 Department of Radiation Oncology Department of Urology
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2012年第2期241-242,共2页 亚洲男性学杂志（英文版）
分类号 Q513 [生物学—生物化学] Q78 [生物学—分子生物学]
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参考文献10

  • 1Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY et al. A Cullin3-KLHL20 ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. Cancer Cell 2011; 20: 214-28.
  • 2Pipinikas CP, Carter NO, Corbishley CM, Fenske CD. HIF-1alpha mRNA gene expression levels in improved diagnosis of early stages of prostate cancer. Biomarkers 2008; 13: 680-91.
  • 3Kimbro KS, SimonsJW. Hypoxia-inducible factor-1 in human breast and prostate cancer. Endocr Relat Cancer 2006; 13: 739-49.
  • 4Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-32.
  • 5Bernardi R, Guernah I, Jin 0, Grisendi S, Alimonti A et al. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 2006; 442: 779-85.
  • 6Lee YR, Yuan WC, Ho HC, Chen CH, Shih HM et al. The Cullin 3 substrate adaptor KLHL20 medi?ates DAPK ubiquitination to control interferon responses. EMBO J 2010; 29: 1748-6l.
  • 7Mak P, Leav I, Pursell B, Bae 0, Yang X et st. ERbeta impedes prostate cancer EMT by destabilizing HIF- 1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell 2010; 17: 319-32.
  • 8Jans J, van Dijk JH, van Schelven S, van der Groep P, Willems SH et al. Expression and localization of hypoxia proteins in prostate cancer: prognostic implications after radical prostatectomy. Urology 2010; 75: 786-92.
  • 9Vergis R, Corbishley CM, Norman AR, Bartlett J, Jhavar S et al. Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials a"d one surgical cohort study. Lancet Oncol 2008; 9: 342-5l.
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Asian Journal of Andrology
2012年 第2期

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