十二指肠乳头旁憩室与胆胰疾病的关系

Relationship between periampullary diverticula and pancreaticobiliary disease

目的探讨十二指肠乳头旁憩室(PAD)与胆胰疾病的关系。方法通过十二指肠镜下逆行胰胆管造影(ERCP)镜下观察PAD的特点,分析PAD与胆胰疾病的发病关系。结果 PAD患者发病随年龄增大而升高,PAD患者胆道结石发病率明显高于非PAD组(P<0.001),其中原发性胆总管结石(P=0.004)和胆道探查术后复发性胆总管结石(P=0.022)高于非PAD组。边缘型PAD并发胆道结石高于并列型和包绕型(P=0.028),PAD直径3.0以上并发胆道结石高于PAD直径3.0以下患者(P=0.001)。PAD组胰头癌发病率与非PAD组有显著统计学差异(P<0.001)。结论十二指肠乳头旁憩室可能是胆胰疾病的病因之一。

Objective To probe the the relationship between the periampullary diverticula（PAD） and pancreaticobiliary disease.Methods The etiological relationship between PAD and pancreaticobiliary disease was analyzed through the observation on the PAD characteristics with ERCP via duodenoscope.Results The incidence of PAD increased with age.The incidence of PAD patients over the age of 70 was significantly higher（P 0.01） than that of controls.The incidence of primary common bile duct stones in patients with PAD was significantly higher（P = 0.004） than that of controls.Carcinoma of head of pancreas was found more often（P = 0.031） in PAD patients（6.31%） than that in controls（3.19%）.Conclusion PAD should be included in the list of possible etiological factors of pancreaticobiliary disease.