白癜风患者焦虑状态与血清中血管紧张素Ⅱ水平的研究

Anxiety state and serum angiontensin H levels in patients with vitiligo

目的探讨白癜风患者焦虑情绪与血清中血管紧张素Ⅱ水平的关系。方法选择60例进展期白癜风患者和健康体检者30例，采用焦虑自评量表（SAS）对两组进行情绪评分，并比较分析两组之间及焦虑与无焦虑患者血清中血管紧张素Ⅱ水平。结果白癜风患者组SAS评分（46．13±11．72）明显高于正常对照组（36．73±12．59），t=3．50，P〈0.01。白癜风患者焦虑情绪发生率为48，3％。女性患者SAS评分和焦虑发生率比男性患者显著增高（t=2．47，r=4．58，P值均〈0．05）。未婚白癜风患者SAS评分和焦虑发生率比已婚患者显著增高（t=2．59，P〈0．01；r=6．17，P〈0．05）。暴露部位白癜风患者SAS评分和焦虑发生率比非暴露部位患者显著增高（t=3．60，P〈0．01；x2=5．84，P〈0．05）。白癜风患者中具有焦虑情绪者血清中血管紧张素Ⅱ水平为（63．83±10．92）ng／L，明显高于无焦虑情绪者（40．74±8．70）ng／L，t=9．09，P〈0．01。结论白癜风患者存在明显的焦虑情绪，且患者血清中血管紧张素Ⅱ水平与白癜风发病及焦虑状态关系密切，可能影响白癜风的发生与发展。

Objective To evaluate the possible correlation between anxiety state and serum angiontensin il levels in patients with vitiligo. Methods Sixty patients with progressive vitiligo and 30 normal human controls were included in this study. Self-rating anxiety scale （SAS） was used to evaluate the anxiety state, and enzyme linked immunosorbent assay was performed to determine the serum level of angiontensin I1, in these subjects. Results SAS score was significantly increased in patients compared with the controls （46.13 ± 11.72 vs. 36.73 ± 12.59, t = 3.50, P 〈 0.01）, and 48.3% of the patients were affected by anxiety. The SAS score and prevalence of anxiety were statistically higher in female than in male patients （t = 2.47, X2 = 4.58, both P 〈 0.05）, in unmarried than in married patients （t = 2.59, P 〈 0.01; x2 = 6.17, P 〈 0.05）, in patients with lesions on exposed areas than in those with lesions on unexposed areas （t = 3.60, P 〈 0.01; X2 = 5.84, P 〈 0.05 ）. In patients affected by anxiety, the level of serum angiontensin 11 was significantly elevated compared with patients without anxiety （63.83 ± 10.92 vs. 40.74 ± 8.70 ng/L, t = 9.09, P 〈 0.01）. Conclusions Patients with vitiligo are usually affected by anxiety. The serum level of angiontensin II is closely correlated with anxiety state in patients with vitiligo as well as with the development of vitiligo, and may have an impact on the initiation and progression of vitiligo.