糖基化终末产物与老年人群认知功能障碍的关系

Advanced glycosylation end products and cognitive functional impairment in the elderly

目的分析老年人群认知功能障碍与糖基化终末产物（AGEs）的关系。方法选择南方医科大学珠江医院神经内科门诊患者及体检中心体检人员中60岁及以上的老年人共270例进行研究。根据蒙特利尔认知评估量表（MoCA）评分将270例研究对象分为认知功能正常N（n=139）及认知功能障碍组（n=131）。荧光分析法检测2组研究对象血清中AGEs含量，分析年龄、性别、文化程度及AGEs含量与MoCA评分的关系。结果2组研究对象血清AGEs含量差异无统计学意义（P〉0．05）。不同年龄段研究对象之间MoCA评分及认知功能障碍检出率差异有统计学意义（P＜0．05）。不同文化程度研究对象间认知功能障碍者的检出率差异有统计学意义（P＜0．05）。结论年龄与文化程度对老年人群认知功能障碍的发生存在一定影响；血清AGEs水平与老年人群认知功能障碍无关，不能作为早期诊断阿尔茨海默病的实验室指标。

Objective To investigate the relationship between advanced glycosylation end products （AGEs） and cognitive functional impairment in the elderly. Methods The present investigation enrolled 270 outpatients aged 60 years and above who had presented to the Department of Neurology or Health Check-up Center, Zhujiang Hospital. They were divided into a normal cognition group （rF139） and a cognitive impairment group （n=131） according to Montreal Cognitive Assessment （MoCA） scores. Their fasting serum was collected to measure AGEs content by fluorimetry in both groups. Associations between their MoCA scores and their age, gender, education and AGEs content were analyzed. Results The AGEs contents were not significantly different between the 2 groups （P〉0.05）. The MoCA scores or the detectable rates of cognitive impairment were significantly different among different age groups （P〈0.05）, but not between genders （P〉0.05）. The detectable rates of cognitive impairment were significantly different among subjects with different educational levels （P〈0.05）. Conclusions Age and educational level are significant factors associated with cognitive impairment in the elderly population. Since the serum AGEs level is not linked to the impaired cognitive function in the elderly, it cannot be used as a laboratory index in early diagnosis of Alzheimer disease.