结直肠癌中NOB1基因的表达及意义

Expression of NOB1 and its significance in colorectal cancer

目的探讨NOB1在结直肠癌中的表达及其意义。方法用免疫组织化学SP法对60例结直肠癌和癌旁正常组织(距癌组织大于3.0 cm)中NOB1的表达进行检测;并分析其与结直肠癌临床病理因素的关系。结果 NOB1在结直肠癌组织中表达阳性的有32例(53.3%),NOB1在癌旁正常组织中表达阳性有10例(16.7%),差异有统计学意义(P<0.05)。在结直肠癌组织中NOB1的表达与患者性别、年龄、肿瘤组织的分级和淋巴结转移均无关(P>0.05)。结论 NOB1在结直肠癌中表达升高,可能在结直肠癌的发生发展过程中起重要作用。NOB1能否成为结直肠癌治疗的新靶点,有待进一步研究。

Objective To investigate the expression of NOB1 in colorectal cancer and its relationship with the clinicopathological characteristics.Methods The expression of NOB1 was detected immunohistochemically in 60 primary colorectal cancer tissues and the corresponding normal epithelia（3.0 cm away from the cancer margin） and graded according to the staining intensity and the percentage of positively stained tumor cells.Results NOB1 overexpression was found in 32 of the 60 cases（53.3%）.NOB1 overexpression in the adjacent non-neoplastic tissues was found in 10 of the cases（16.7%）,a rate significantly lower than that in the cancer tissues（P0.05）.NOB1 expression was not correlated to such tumor characteristics as gender,age,histological differentiation grade,depth of invasion and lymph node metastasis（P0.05）.Conclusions NOB1 expression is higher in colorectal cancer than in normal colorectal tissues,suggesting its involvement in the tumorigenesis and progression of colorectal cancer.