诱导缓解期残留白血病细胞比例在中间核型急性髓系白血病中的预后价值
摘要
目的评价诱导缓解期残留白血病细胞比例在中间核型急性髓系白血病(AML)的预后价值。方法 60例中间核型AML患者在诱导缓解化疗末(T1时点)及骨髓抑制期(T2时点)取骨髓涂片行形态学检查,分析不同时点骨髓白血病细胞比例对完全缓解(CR)、无病生存(DFS)及总体生存(OS)的影响。结果单个时点(T1或T2)白血病细胞比例划分的2组CR率、3年DFS及3年OS比较差异均有统计学意义(P<0.05),多变量分析显示单时点的白血病细胞比例是影响CR、DFS、OS的独立预后因素(P<0.01)。联合两个时点的白血病细胞比例划分的4组在CR率、3年DFS及3年OS差异均有统计学意义(P<0.01)。结论联合两时点的白血病细胞比例可对中间核型AML再精确分组,指导个体化治疗。
出处
《河北医药》
CAS
2012年第5期668-670,共3页
Hebei Medical Journal
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