GP73在原发性肝癌组织中的表达及意义

Expression and significance of Golgi protein 73 in hepatocellular carcinoma tissue

目的探讨高尔基体糖蛋白73(GP73)表达诊断肝癌的价值。方法采用免疫组织化学染色SP法检测60份肝癌组织、癌旁组织及24份正常肝组织中GP73表达;分析GP73表达与肝癌临床病理特征的关系。结果肝癌组织、癌旁组织GP73阳性率显著高于正常肝组织(P<0.05)。GP73表达与Child-Pugh分级呈正相关(P<0.05),在肝外转移和HBV感染中表达亦显著增强(P<0.05),与性别、年龄、AFP、肿瘤大小、肝硬化和门脉癌栓无明显相关性。结论 GP73与肝癌的发生发展有关。

Objective To investigate the value of golgiprotein 73（GP73） in diagnosing hepatocellular carcinoma（HCC）.Methods The immunohistochemical SP staining technique was used to detect the expression of GP73 in 60 cases of HCC,adjacent tissue and 24 normal controls;the correlation between the expression of GP73 and clinical pathology parameters of HCC was analyzed.Results The positive rate of GP73 expression was significantly higher than that in HCC and adjacent tissue（P0.05）.The expression of GP73 was positively correlated with Child-Pugh（P0.05）,and enhanced markedly in the extrahepatic metastases and HBV infected tissue（P0.05）,but not correlated with age,gender,AFP,tumor size,cirrhosis,and portal vein tumor thrombus.Conclusion GP73 is correlated with the occurrence and development of HCC.